New research suggests that people who come off blockbuster slimming jabs like Mounjaro or Wegovy can put back on shed pounds far faster than those who end traditional diet and exercise programs.
Published data in a prominent medical journal shows that while obese people frequently drop about a fifth of their body weight while using the jabs, the mass comes back at an estimated rate of nearly a kilo each month once they quit.
"Individuals purchasing such drugs must be cognizant of the danger of rapid weight regain when the medication is stopped," warns lead investigator Dr. Susan Jebb.
This pace of recovery implies a return to starting mass in about a year and a half.
Weighing Approaches
The study, which looked at dozens of trials involving thousands of participants, compared the results of the injectable medications with older methods.
The team emphasize that individuals who shed pounds through diet and exercise usually have a less rapid weight regain—approximately 0.1 kg a month—after stopping.
Understanding the Fast Regain
Doctors believe the mechanism of the drugs is key to understanding the amplified weight return.
The injections mimic a body's own chemical called glucagon-like peptide-1, which controls hunger.
"Long-term administration of GLP-1 levels several times higher than the body's typical production could lead to the system to generate a reduced amount of its endogenous hormone, and may also lessen responsiveness to its actions," explained Dr. Adam Collins, a dietetics specialist.
"Stopping of this medication leads to appetite is no longer kept in check, making excessive eating a significant risk."
A Chronic Disease?
Health authorities suggest the injections for individuals with obesity-related health risks, accompanied by recommended lifestyle changes.
A number of clinicians say that, due to the high risk of weight regain, the treatment should be considered long-term.
This opinion is supported by pharmaceutical companies, who note that the results "emphasize the persistent character of excess weight," similar to managing conditions like hypertension.
Patient Accounts
Users who have come off the medication report a sudden return of appetite.
"It felt as if a trigger activating and I was suddenly starving," said one woman.
This difficulty is compounded if patients have not developed sustainable lifestyle or habit modifications during treatment.
Significant Adoption
Survey data indicate that millions of people in the UK have tried weight-loss jabs in the last 12 months, with interest continuing to grow.
- Adoption is higher among women compared to males.
- The middle-aged age group shows the highest level of interest.
- Many access the drugs through private healthcare rather than public health services.
In conclusion, researchers caution that while GLP-1 drugs are potent tools for weight loss, they are not a permanent cure and long-term success relies on integrated lifestyle changes.
